Increasing number and amount of industrial, agricultural and commercial chemicals discharged in to the aquatic environment have lead to various deleterious effects on the aquatic organisms. The liver and kidney plays central role in the process of digestion and excretion metabolism. This organ has a number of functions in the body, including detoxification, plasma protein synthesis, glycogen storage and production of metabolites necessary for digestion. In the present study fish was exposed to 0.25 ppm. of heavy metals (LC50/6 values of 72 hours) up to 18 days. The present study of Cadmium trioxide treated fish, O.mossambicus liver, kidney shows disarrayed cords and showing pronounced vacuolization and necrosis. Karyolysis is also observed. Scattered erythrocytes, pronounced damage has been observed. Severe damage in comparison in 18 days exposure indicate that damage in the liver, kideney are indirectly related to dose and duration of treatment.
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