Aim:To compare and evaluate the effect of Bioceramic sealers with Bioceramic Impregnated GuttaPercha on the fracture resistance of endodontically treated teeth. Materials and Methods: A total of thirty single-rooted mandibular premolar teeth weredecoronated to standardize the root length of 13mm.Cleaning and shaping was done and the samples were randomly divided into three groups. Group I: Bioceramic Sealer (Ceraseal B) with Bioceramic Impregnated GuttaPercha (SURE ENDO), Group II: Bioceramic Sealer (Ceraseal B) with normal GuttaPercha, Group III: AH Plus sealer along with normal gutta-percha. All the teeth were embedded in acrylic resin blocks and fracture force was measured using a universal testing. Then, the data will be statistically evaluated using two-way analysis of variance (ANOVA). Results:The fracture resistance of group III >group II> group I. However, the results were statisticllay not significant .Ceraseal-B sealer along with bioceramic impregnated gutta-percha (BIO-GP) showed the maximum fracture resistance compared to the other two groups. Conclusion:From this study, it can be concluded that the fracture resistance of Ceraseal-B sealer with Bio GP Points was better than that of Ceraseal-B sealer with traditional gutta-percha, although the difference was not statistically significant. The bioceramic sealer (Ceraseal- B) combined with Bio GP Points had a better fracture resistance than that of AH Plus sealer with traditional gutta-percha and the difference was statistically significant.