A 31 years old woman has undergone treatment with methroxate because of ectopic pregnancy (EP). She had a typical ultrasound appearance of ectopic pregnancy in her right adnexa. She followed the therapeutical protocol of methotrexate (MTX) in our clinic but the unusual point of view in our case was that her first value of β-hCG was very high, starting from 13827 IU and was increasing the following days. This was in controversy with the until today, guidelines choosing methotrexate for the treatment. The results and her clinical appearance is discussed in the following text.