Surgery is the mostly the treatment of choice or indication and major therapy in the management of malignancy of breasts. Drain placement in post-mrm patients is one method to drain the seroma formed after the surgery. The drain-release protocol varies in each hospitals. This study aimed to compare early drain release with late drain release in postoperative MRM patients. The present study is a prospective cohort study in 60 patients with drain remove and the recording of the proportion of seroma formation and aspiration actions on days after drain release, infection, flap necrosis.