Mononuclear manganese(II) complexes having NNN-donor 4'-(1H-thiophen-2-yl)-2,2':6',2''-terpyridine base has been prepared and characterized by various physico-chemical techniques. Manganese(II) complexes show strong ligand to metal charge transfer (LMCT) band in the region of 340-350 nm. Agarose gel electrophoresis method has been employed to study the DNA cleavage behavior of the complexes. The synthesized ligands and complexes have been tested for in vitro growth inhibitory activity against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and two fungi (Aspergillus niger and Candida albicans). Both the ligand and complexes exhibit better antimicrobial activities. But the antimicrobial activity of the complexes has been found to be higher due to its chelating nature.
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2022: 6.012
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