Distribution pattern of gstm1 and gstt1 gene in vindhyan region population

GST enzymes, which are encoded by GST genes, are responsible for the detoxification of chemicals found in the environment and naturally synthesized metabolites, and they play an important role in protecting tissue from oxidative damage. In this study, we aimed to investigate distribution pattern of GSTM1 (Present/Null) and GSTT1 (Present/Null) in the central Indian population of Madhya Pradesh. Sample were collected from regional institution and PCR based method were used to detect presence and null genotype of GSTM1 and GSTT1. Overall distribution pattern of GSTM1 present/null genotype suggest majority of vindhyan region population do not carry GSTM1 in either form meanwhile GSTT1 is also present in lower frequency. our finding suggest that increased burden of cancer occurance may be because of absence of these drug metabolizing genes.