Substance abuse is defined as a pattern of detrimental use of any substance for mood-affecting non-medical purposes, with alcohol being the most common. Alcohol is a highly potent drug that causes acute and chronic changes in every neurochemical system. The cardinal features of Madatyaya (as indicated in Ayurvedic treatises) may be seen in the context of alcoholism. Here is the case report of a 52-year-old man who visited the Out Patient Department of Panchakarma at Sri DharmasthalaManjunatheshwara College of Ayurveda and Hospital, Hassan with complaints of sporadic headaches in the morning, disturbedsleep, occasionaltremor, angerspells for the past oneyear. After thorough interrogation, he was diagnosed with a case of Vatapittajamadatyaya, so treatment was carried out through a novel combination of Dhanyakahimabasti for 11 days. Symptoms were assessed before and after treatment with CIWA scale and Insomnia screening scale which showed significant results before and after treatment. This novel combination was found to be effective in this case but to establish this modality of treatment further study should be carried out.