Enterococci have transformed over the past century from being an intestinal commensal organism of little clinical importance to becoming the second most widespread nosocomial pathogen and is related with considerable mortality and morbidity. In this study a total of 20 different non-repetitive clinic isolates of Enterococci were collected from different clinical specimens and checked for inducible clindamycin resistance. Enterococcus isolates were subjected for susceptibility to erythromycin and other group of antibiotics by the Kirby-Bauer disc diffusion method. Of the 20 isolates, 18 (90%) of them were erythromycin resistance. The clinician must have a wide knowledge of inducible clindamycin resistance and report to laboratory immediately for prompt treatment. The D-test is a simple & reliable method to detect inducible & constitutive clindamycin resistance in routine clinical diagnosis setting.