The aim of present research work is to develop an ideal floating drug delivery system using montelukast sodium to increase the gastric residence time in stomach and to assess the in-vitro quality control tests for prepared tablet formulation. Materials and Methods: In this study montelukast sodium tablets were prepared using xanthan gum, guar gum, karaya gum as polymers, sodium bicarbonate as gas releasing agents, citric acid as acidifying agents, and magnesium stearate as flow promoters and SMCC HD 90 as a diluent. The direct compression method was used by using a rotary compression machine. Before compression, granular material was evaluated for precompression parameters such as angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. After punching, tablets were evaluated for weight variation, friability, hardness, drug content, floating lag time, buoyancy, and cumulative percent drug release. The formulations were optimized for different concentrations of guar gum, karaya gum, and xanthan gum and their formulations. Optimized formulations were subjected to stability studies and characterization by FTIR. Results and Discussion: All prepared tablets showed good in-vitro buoyancy for >9 to>24hours. Optimized formulation showed cumulative percent drug release of 99.8±0.14 %, buoyancy lag time 39.06±0.03sec and duration of buoyancy >24±0.3. Release kinetics of optimized formulation showed zero order with non-fickian diffusion. Conclusion: Out of all nine formulations, F3 has 40mg of xanthan gum and was considered as best formulation based on buoyancy, swelling studies and drug release mechanism corresponds to zero order and non-fickian diffusion.
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