The main objective of this study was to develop and evaluate novel oral in- situ gels of Herbal Curcumin to get sustain action for Peptic Ulcer treatment. The formulations are prepared by using sodium alginate as a natural biodegradable polymer, Calcium carbonate as a cross linking agent, and Peanut husk Powder as a floating agent. Initially the formulation is in sol form once taken orally it reacts with gastric pH and it changes to gel form. Various evaluation tests were conducted and from the results it was evident that formulation F4 containing 2.5 % of sodium alginate and 1% peanut husk powder has shown good viscosity, drug content 98.99%, pH, in vitro gelling capacity, better floating efficacy >12hrs and sustained drug release 98% for 14 hrs and it was found to be stable. Finally peanut husk powder can be used as a floating agent in in-situ preparations for getting sustained action due to its low density and its cost effectiveness.
Impact Factor
2022: 6.012
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