Dilated cardiomyopathy (DCM) is one of the common form of cardiomyopathy and major cause of morbidity and mortality worldwide. Thyroid hormone plays a major role in cardiac function. Material & method: The cross sectional study was conducted at the department of General medicine, Calcutta National Medical College & Hospital in collaboration with department of cardiology. 100 patients of dilated cardiomyopathy were studied after matching inclusion and exclusion criteria from outdoor and inpatients over period of 18 months from January 2019 to June 2020.
Result: In our study 44% patients were male and 56% female. 15% patients were diabetic. 53% were in NYHA grade IV heart failure. TSH ranges from 0.1 uIU/ml to 16 uIU/ml. Mean TSH was 3.281 ± 2.681 uIU/ml. The mean LVEF in subclinical hypothyroid, hypothyroid, euthyroid and subclinical hyperthyroid were 31.50 %, 28.00%, 32.18% & 29.50 % respectively. In our study, on comparing left ventricular ejection fraction (%) with TSH (uIU/ml) in all patients as well as euthyroid, the scatter plot showed negative correlation implying that with increasing values of TSH, the left ventricular ejection fraction showed a decreasing trend. Similarly, on comparing left ventricular ejection fraction (%) with fT4 (ng/dl) in all studied patients as well as euthyroid, the scatter plot showed positive correlation, that a higher fT4 (ng/dl) was associated with higher ejection fraction, similarly lower fT4 (ng/dl) was associated with lower ejection fraction. Conclusion: An increase in thyroid dysfunction was found in patients who had a longer duration of dilated cardiomyopathy. Patients with diabetes as a comorbidity were found to present with more severe heart failure (NYHA class IV). A statistically significant positive correlation between left ventricular ejection fraction (LVEF) and fT4 (ng/dl) was observed even in the euthyroid population.
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2022: 6.012
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