Background: The presence of peripheral arterial disease in chronic renal failure portends a dismal prognosis due to the increased morbidity and mortality from cardiovascular events. Peripheral arterial disease is asymptomatic in about 40%.
Aims: The study was designed to identify the prevalence of the peripheral arterial disease in chronic renal failure, which is a state of accelerated atherosclerosis.
Materials and methods: It is cross-sectional study of 50 patients with chronic renal failure attending the outpatient were assessed for the prevalence of peripheral arterial disease by measuring the Ankle-brachial index. Age, gender, hypertension, and ischemic heart disease profiles of the sample were analyzed for association with peripheral arterial disease.
Results; The majority of the patients belonged to the age group 41-50 years. 46 were males, 4 were female patients. 4 out of 50 patients in the sample had symptoms suggestive of peripheral arterial disease. 20% (n=10) had evidence of ischemic heart disease. Hypertension was present in 40% (n=20) of the patients. 50% of the patients belonged to CRF stage 4.The prevalence of peripheral arterial disease as determined by and ABI<0.9 was 30%. Among the variables studied, the presence of IHD (p=0.008) and creatinine clearance(p=0.0002) were identified as having a significant association with increased prevalence of PAD. All symptomatic patients had the peripheral vascular disease (ABI<0.9) but of the asymptomatic patients23.7%(n=11) had evidence of PAD. There was an inverse correlation between creatinine clearance and the prevalence of PAD.
Conclusion: There was a significant relationship between the prevalence of peripheral arterial disease and the stage of chronic renal failure, the higher the degree of renal insufficiency the higher was the prevalence of the peripheral arterial disease
Impact Factor
2022: 6.012
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