Correlation of the Severity of Atopic Dermatitis with Absolute Eosinophil Count in Peripheral Blood and Serum IgE Levels

Background: Atopic dermatitis (AD) is a common inflammatory skin condition with a relapsing and remitting course1 that affects all ages but is more common in children. AD prevalence is high in developed and high-income countries which is nearly 10-30% in children and 2-10% in adults, it also shows that there is a 2-3-fold increase in prevalence over the past few decades.2 The increased serum IgE levels and the absolute eosinophil count shows correlation with AD severity.4 Methods: A prospective descriptive study was conducted in DVL department, Government General Hospital, Kurnool Medical College, Kurnool with a sample size of 50 patients. Results: AD was common in age groups of 0-1 year (22%) and 1-5years (56%) with a Male: Female ratio of 1.38:1 of which 44% belonged to middle and 38% to lower socio-economic status. Family history and personal history of atopy were noted in 58% and 68% of the cases respectively. Pruritus was seen in 100% of cases and xerosis in 96% of cases. Conclusions: Elevated AEC and serum IgE levels were noted in 74% and 82% respectively. Mean AEC and Mean serum IgE levels showed correlation with the severity of the disease.