Background: Diabetes is a long-standing disease characterized by hyperglycemia.Insulin resistance (IR) is the key pathophysiological defect that leads to the development of type 2 diabetes mellitus. The trace elements are association with insulin resistance.
Objectives: The purpose of the present study was to estimate serum zinc, magnesium, copper and insulin resistance (HOMA-IR) in type 2 diabetes mellitus patients and to see the correlation between them.
Material and methods: The present study was carried out in the Department of Biochemistry on 320 subjectsin the age group of 35-70 years, attended OP in Rama Medical College and Hospital. Among them 160 healthy subjects enrolled as control group remaining 160 T2DM patients were served as case group. Fasting venous blood sample was analyzed for fasting blood sugar (FBS), serum zinc, serum magnesium, serum copper and serum insulin. Insulin resistance was calculated by HOMA-IR method. Statistical analysis was done using student ‘t’ test. Pearson’s correlation between the study variables was performed to establish the relationship.
Results: The FBS, serum copper and Insulin resistance levels were significantly elevated in diabetics compared to healthy controls (p<0.001). There was significant decrease in the levels of serum zinc and magnesium levels in diabetics compared to the controls (p<0.001). A positive correlation found between serum copper with Insulin resistance, and a negative correlation found between serum zinc and magnesium with Insulin resistance in diabetic patients.
Conclusion: Diabetic patients showed anegative correlation between serum zinc and magnesium with insulin resistance and positive correlation found between serum copper with insulin resistance.
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