Contemporary regenerative materials from peptides and platelet-derived growth factor

Periodontal regeneration is the reproduction or reconstitution of a lost or injured part to restore the architecture and function of the periodontium. Various regenerative materials have been used in the treatment of periodontitis. Mostly used regenerative materials are bone grafts, PRF, PRP, etc. which have been demonstrated to have significant regenerative potential. Recently, regenerative materials are developed from peptides (PepGen P-15) and platelet-derived growth factor (GEM 21S). PepGen P-15 is an anorganic bovine-derived hydroxyapatite bone matrix that is combined with cell-binding peptide P-15. GEM 21S is a combination of highly purified recombinant human platelet-derived growth factor (rhPDGF-BB) and beta-tricalcium phosphate (β-TCP). This article aims to provide an insight into these regenerative materials so as to provide the clinician with some practical rationale in the treatment of periodontal intrabony defects.