Comparison of wbc- total and differential count in different trimesters of pregnancy

Background: - Pregnancy is a state characterized by changes in many physiological and haematological parameters. Most earlier studies conducted emphasized mainly on Haemoglobin and RBC parameters changes in pregnancy but there have been only a few studies on changes in WBC -total and differential count parameters in pregnancy. Leukocytosis in pregnancy is seen mainly due to neutrophilia with slight left shift along with toxic granulation associated with stress. The aim of this study was to assess the changes in total and differential leucocytes count in pregnancy in comparison with non-pregnant controls in different trimesters in pregnancy. The cross sectional study was conducted in Department of Pathology, Index Medical College Hospital and Research Centre, Indore during October 2013 to September 2015. A total 400 blood samples from pregnant women and non-pregnant women each were collected and run on fully automated 5part differential hematology analyser Transasia Model-XS-800i. Detail parameters including WBC- total and differential count were done and compared in different trimesters of pregnancy. In our study around two third females were in age group of 21-30 years. In total 39%, 38.75% and 22.25% women were in first, second and third trimester respectively. Comparison of mean between three trimesters was done. Total WBC count, Neutrophils and Lymphocytes count showed significant difference, while Monocytes, Eosinophils and Basophiles did not show any significant correlation. Significant increase in WBC and Neutrophil count were seen in pregnant women. There was significant difference in WBC count and neutrophils between first-second and first -third trimesters.