Background: Intraocular pressure (IOP) measurement and thorough eye examination are needed for management of retinoblastoma patients. Most children have to be anesthetised for proper eye examination and these anaesthetic agents have tendency to alter IOP. Therefore we aim to compare the effect of ketamine and sevoflurane on IOP in children having retinoblastoma.
Methods: In this prospective study, 100 patients with ASA I/II, for eye examination under anaesthesia were enrolled and randomized into two groups (50 each). Group K was induced byintravenous ketamine 2.0 mg/kg andGroup S byinhalational sevoflurane 8%. IOP was measuredin both eyes at 4 min, 8 min, 12 min and 16 min. The hemodynamic parameters and oxygen saturation were also recorded.
Results: Mean IOP was higher in Group K than Group S at all periods. In Group K the largest increase in IOP from baseline was observed between 8 min to 12 min after that IOP started decline. This decrease in IOP from 12 to 16 min was statistically significant (p<0.001). Blood pressure and heart rate were significantly greater in ketamine group at all time periods.
Conclusion: Ketamine had significantly increased the IOP and sevoflurane decreased IOP. Increase in IOP was transient and it does not cross the boundary of clinical significance. Ketamine may be preferred over sevoflurane to avoid falsely low IOP measurement.
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2022: 6.012
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