Comparision of ocular hypotensive effect of bimatoprost versus timolol brimonidine fixed combination in open angle glaucoma patients

Purpose: To compare the ocular hypotensive efficacy and safety of topical Bimatoprost and fixed combination Brimonidine and Timolol maleate in. Method: Fifty patients of primary open angle glaucoma and Ocular hypertnsion patients were divided into 2 groups of 25 each. Group A received Bimatoprost 0.03% once daily and Group B received fixed combination Brimonidine tartarate 0.2% and Timolol maleate 0.5% twice daily (FCBT). Intraocular pressure was measured at 9am, 1pm and 4pm at first visit, 1 week, 1month, 3month and 6 month. Mean diurnal IOP and mean IOP at 9am, 1pm and 4 pm were the outcomes measured. Result: Mean diurnal IOP reduction for Bimatoprost and FCBT were 32.5% and 29.7% respectively. Bimatoprost group had lower mean IOP at 1pm and 4 pm (p<.001). 76% of eyes on Bimatoprost achieved IOP of < 18mmHg while 28%
had IOP <18 mmHg with FCBT. No serious adverse effect was observed with either drug. Conclusion: Bimatoprost has higher IOP lowering efficacy and better diurnal control than FCBT. Both drugs are well tolerated.