Various periodontal regenerative materials have been used for periodontal regeneration to treat periodontal diseases successfully. Apart from nonsurgical treatment, Surgical periodontal regeneration also plays a vital role in treating periodontal diseases. Stem cell Biology and Regenerative Medicine have been proved very useful in the field of periodonticsas tissue engineering and genetic therapy in periodontal regenerative therapy. Amniotic membrane has a wide range of benefits in periodontal regenerative therapy as it eliminates scarring and inflammatory condition, also improves wound healing, and also works as a scaffold for tissue regeneration, apart from these it also great antimicrobial properties and can be easily procured from the source, processed, can be stored and transported easily.