Comparative evaluation of salivary advanced oxidative protein products (aopp) levels in chronic periodontitis in association with metabolic disorder (type ii diabetes mellitus)

Introduction: Advanced Oxidative Protein Products (AOPP) are a family of oxidized, dityrosine containing protein products formed as a result of oxidative stress, considered as a novel markers of oxidant-mediated protein damage. An emerging body of evidence suggests oxidative stress to play an important role in pathogenesis of periodontal tissue destruction and type 2 diabetes mellitus (T2DM).
Aim and Objectives: To quantify AOPP levels in periodontal health and disease, with and without T2DM and compare it with clinical parameters.
Methodology: Total of 100 subjects, Group I:25 periodontally healthy subjects; Group II:25 subjects with chronic periodontitis (CP); Group III:25 periodontally healthy subjects with T2DM; Group IV:25 subjects of CP with T2DM. Unstimulated whole saliva samples were collected after obtaining duly signed informed consent. AOPP were determined using UV spectrophotometry at 340nm.
Results: AOPP levels for group-II and group-IV were significantly higher than the group-I & group- III.
Conclusion: The well-established relation between AOPP response and inflammation suggests that it is the best marker for monitoring oxidative stress mediated protein damage in chronic inflammatory conditions. AOPP accumulation can be a therapeutic target for the prevention and delaying the progression of micro and macrovascular complications.