Background: Interleukin-18 (IL-18) is an important regulatory cytokine in non-oral inflammation. It is a pro-inflammatory and tumor suppressive cytokine, which, due to its structure receptor family, and signal transduction pathways belongs to the IL-1 cytokine family. The aim of the present study was to determine the GCF levels of IL-18 in healthy, Gingivitis and Chronic Periodontitis subject pre and one month post scaling and root planing (SRP).
Materials and Methods: Study consisted of 60 subjectswho were divided into 3 groups i.e. Healthy, Gingivitis & Chronic periodontitis (CP) consisting of 20 subjects in each group.
Results: There was statistical significant difference between the levels of IL-18 in healthy and diseased group. A marked reduction was seen in all the clinical parameters (p<0.001) as well as in IL-18 levels (p<0.001) following non-surgical periodontal therapy (NSPT) in Gingivitis and Periodontitis group.
Conclusion: IL-18 could be a factor in progression of inflammation because it has chemotactic, pro-inflammatory, and osteoclastic properties. Increased IL-18 levels was seen with severity of the periodontal disease and its levels decreased following successful periodontal treatment.
Impact Factor
2022: 6.012
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