Aim: The purpose of this study is to compare the fracture resistance of endodontically treated teeth using two different sealers AD seal (resin-based) and CERASEAL (bioceramic sealer) with various irrigation protocols. Material And Method: 32 single-rooted teeth were distributed in 2 groups characterized by the different cleansing system used: conventional endodontic needle irrigation and Passive ultrasonic irrigation (PUI). Root canal preparation was carried out using ProTaper rotary files and 3% sodium hypochlorite. After preparation, the specimens were subdivided into four groups. Group I A: needle irrigation and obturated with AD seal, group IB: needle irrigation and obturated with Ceraseal, Group IIA: PUI and obturated with ADseal, group IIB: PUI and obturated with Ceraseal. A vertical load was applied to each specimen using a universal testing machineuntil the roots fractured. Results: The result shows that the group which was obtu¬rated using ceraseal and activated with PUI showed better fracture resistance. This was followed by group II A and group IB. However, the results among the four groups were not statistically significant. Conclusion: The highest fracture resistance was offered by Bioceramic Sealer activated with PUI when compared with resin based sealer