Introduction: Endogenous regenerative technology (ERT) such as platelet rich fibrin triggers the self-repair mechanism and promotes the host’s innate potential for regeneration. Modification of ERT by incorporation of drugs or in conjunction with other regenerative materials have gained interest recently.
Objective: To comparatively evaluate the efficacy of platelet rich fibrin (PRF) with metronidazole, PRF with demineralized freeze-dried bone allograft (DFDBA)and PRF alone in the treatment of infrabony defects both clinically and radiographically.
Methodology: A 48-year-old patient having infrabony defects in four sites was selected using grid IOPA. Clinical parameters like Plaque index, Gingival index, Probing pocket depth and Clinical attachment level was recorded at baseline, 1month, 3months and 6months. The defects in 2 sites were treated with PRF+Metronidazole (MTZ) and either of the other 2 sites with PRF+DFDBA and PRF alone respectively. Open flap debridement was accomplished before the placement of either of the material. Radiographic changes were recorded at 3 months and 6 months.
Results: The clinical and radiographic parameters showed improvement as compared to baseline in all the sites. The sites treated with PRF+MTZ and PRF+DFDBA showed better results as compared to the site treated with PRF alone.
Conclusion: The combination of PRF+MTZ and PRF+DFDBA were proven to be better than PRF alone. Further, long term clinical trials with larger samples should be carried out to assess a complete periodontal regeneration rather than bone regeneration.
Impact Factor
2022: 6.012
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