The present study was carried out to evaluate the antimicrobial and antifungal activity of combine ethanolic extracts of Calendula officinalis and Psidium guajava against two clinically important bacteria and fungi namely Staphylococcus aureus, E. coli andAspergillus flavus, Candida glaberata.The antimicrobial and antifungal activity of combined extracts was done with agar well diffusion assay in plates containing nutrient agar media. The antimicrobial activity of ethanolic extracts showed that all the combinations of extracts were effective against the test microorganisms. The patterns of inhibition varied with the different plant part extracted as the tested microorganisms. The methanolic extract of Psidium guajava and Calendula officinalis showed effective antibacterial and antifungal activity. The combined extracts of Calendula officinalis (petals) and Psidium guajava (leaves) antibacterial and antifungal activity showed reduced zone of inhibition by 10 mm in Aspergillus flavus, 2 mm in Candida glaberata, 4 mm in Staphylococcus aureus and increased by 2 mm in E. coli while comparing with streptomycin and fluconazole.
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2022: 6.012
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