Human Amniotic membrane is a pluripotent cellular element that is embedded in a semipermeable membranous structure. It has several properties like anti-inflammatory, anti-scarring, antimicrobial and antiviral properties, cell differentiation, lack of immunogenicity etc. Amniotic membrane is an excellent membrane because it is ethically acceptable, easy to use, cost effective, and easily stored. Successful applications of HAM in various clinical and surgical fields had been reported for over 100 years. The first documented use of amniotic membrane is as a skin substitute by Davis in 1910. Subsequently the foetal membrane was found to be useful in the management of burns, creation of surgical dressings, as well as reconstruction of the oral cavity, bladder, and vagina, tympanoplasty, arthroplasty and so forth. In Periodontics, these membranes have been used in furcation defects, intrabony defects, and gingival recession coverage.