Introduction: Brain metastases are the most common type of intracranial neoplasm, with the total number outnumbering primary brain tumors by a ratio of 10:1 and occur in about 25% of cancer patients.
Aim: The purpose of this study was to analyze retrospectively the clinical profile and survival of patients with brain metastases.
Materials and Methods: This study analyzed a total of 130 patients with brain metastasis admitted from January 2012 to December 2016. Of these, 101 patients who received whole brain radiotherapy (WBRT) were included in this study. Prognostic factors evaluated for overall survival were age, gender, Eastern Cooperative Oncology Group (ECOG) score, primary histology, number of lesions, location of lesion, primary tumour site, extracranial metastasis. It is a retrospective, descriptive study.
Results: Brain metastases were more common in male and occur in 6th decade of life mostly. Carcinoma lung was the most common primary giving rise to brain metastases followed by breast. Adenocarcinoma accounts for most common histology of the primary that give rise to metastases. Multiple metastases were more common than the single one. Supratentorial lesions were more common than infratentorial lesion. The median overall survival was about 2 months while 1 year survival rate was 7%. In this study, patients with female gender, ductal and lobular as primary histology, solitary metastasis and carcinoma breast as primary had better survival.
Conclusions: Present study highlights that carcinoma lung accounts for majority of brain secondaries. Patients with solitary metastasis and carcinoma breast as primary tumor have comparatively better prognosis. Despite use of radiotherapy survival is poor. So efforts should be made for early diagnosis of brain metastaisis in malignancy of other sites beside breast carcinoma and to incorporate multimodality treatment approaches including radiotherapy, radiosurgery, chemotherapy in treatment.
Impact Factor
2022: 6.012
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