Caffeine serves as a double-edged sword, possessing both advantageous and detrimental impacts on human health. Caffeine is one of the world's oldest beverages and it continues to be a subject of active research for its potential benefits. Whether through coffee, tea, cocoa, and chocolate we regularly introduce various forms of caffeine into our bodies. When consumed moderately, caffeine exhibits several positive effects on our health, but caution is warranted as higher dosages can have harmful consequences. Numerous studies in the literature explore the consumption of caffeine and its potential benefits, predominantly relying on animal models for testing. However, the transition to human studies is essential, especially in utilizing caffeine as a therapeutic drug for managing disease where effective therapy is still elusive. Caffeine’s impact extends to various aspects, including the brain, heart, liver, kidney, and psychological as well. In this context, we have outlined the effects of caffeine, particularly in the realm of neurological disorders.