Present study aimed to investigate the efficiency of bioaccumulation and histochemical changes of Bellamya bengalensis as biomarkers for aquatic metal pollution. The bioaccumulations of heavy metal in reproductive cells were subjected to histological and histochemical analysis against induction of heavy metal cadmium sulphate. Moreover, the histological and histochemical changes in the germinating cells were observed for different exposure periods. Results revealed appreciable alterations of the histochemical content with histopathology as biomarker values with significant correlation of bioaccumulation and toxicity. Study revealed that, to overcome toxic stress animal utilize neutral mucosubstances and in opposite has elevated level of acidic component in reproductive cells showing loss in the regenerative capabilities. The changes were interpreted in relation to their reproductive mechanism against induced cadmium toxicity.