Recurrent aphthous stomatitis (RAS) is inflammation of the mucosa with painful ulcerations in the oral cavity. It is one of the most common disorder seen in primary care, affecting upto 25% of the general population and 3-month recurrence rates are high as 50%. Female predominance is seen. Approximately 2 per cent of patients with RAS present with severe, persistent form of the disease. Although less number of people are affected, the suffering is great. Such patients usually present with history of continual referral between various specialties of the healing profession, with no improvement. This paper deals with such a 20-year old male patient who presented a 4-year history of episodes of multiple recurrent ulcers on the oral mucosa accompanied with severe pain.