Association of insertion/deletion polymorphism of ace gene with hypertension in central indian population

Hypertension is a major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular disease. Advances in the diagnosis and treatment of hypertension have played a major role in recent dramatic declines in coronary heart disease and stroke mortality in industrialized countries. Hypertension is a term related to high blood pressure and it referred to the condition that affects almost one billion people worldwide, and it is a leading cause of morbidity and mortality. Renin angiotensin system (RAS) plays crucial role in the regulation of blood pressure. Association between candidate gene polymorphisms of RAS and EH has been reported in different populations. A PCR based I/D polymorphism study in central Indian patients were perform to detect ACE polymorphism and its pathophysiological role in hypertension. The pattern of genotype and allele distribution in disease and control group suggested no association of ACE I/D in Hypertension susceptibility.