Introduction: Renal transplantation is the treatment of choice for renal replacement therapy in patients with end-stage renal disease. Acute kidney injury due to transplantation could cause adverse effects on the outcome of the transplantation, due to the injury to the transplanted kidney. New studies have demonstrated the effectiveness of dexmedetomidine in preventing acute kidney injury in patients undergoing surgery. This study was designed to assess the effects on dexmedetomidine on renal function in renal transplant recipients.
Materials and Methods: Thirty renal transplant candidates were randomly assigned to either of the control or intervention groups, receiving the standard maintenance or dexmedetomidine, respectively. Renal function was assessed at fixed intervals, using Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.
Results: Twenty patients were assigned to the control group and 10 were assigned to the intervention group. Overall average age was 41.5 years and male to female ratio was 0.88.
There were no significant differences among the two groups regarding age, gender, duration of renal replacement therapy or prevalence of diabetes, hypertension or other comorbidities (p value= 0.32).
Discussion: According to our findings, dexmedetomidine did not have any statistically significant effects on renal function. This finding could be the result of small study sample size or insufficiently accurate measurement methods. Therefore, we suggest that further studies be carried out.
Impact Factor
2022: 6.012
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