Antimicrobial efficacy of silver nanoparticles against periodontal pathogens

Background: Plaque accumulation on the teeth surfaces and the prosthetic or
orthodontic appliances presents a serious challenge for the maintenance of oral health. Silver nanoparticles can be incorporated in the restorative materials to prevent plaque formation and progression of periodontal diseases.
Aim: To evaluate the antimicrobial efficacy of silver nanoparticles by calculating minimum inhibitory and bactericidal concentration of silver nanoparticle.
Materials and method: Antimicrobial efficacy of nanosilver was evaluated against specific periodontal pathogens (P.gingivalis, A.actinomycetemcomitans, P.intermedia). Minimum inhibitory (MIC) and bactericidal concentration (MBC) was determined using broth dilution assay. A commercially available silver nanoparticles gel (0.02mg/gm) was used for the study.
Results: P.gingivalis, A.actinomycetemcomitans were sensitive to silver nanoparticles. However, P.intermedia was found to be resistant. Conclusion: Nanosilver has anti-bacterial effect against P.gingivalis, A.actinomycetemcomitans. Future studies are needed to explore the applicability of these silver based antimicrobial agents in clinical dentistry.