Anti-inflammatory, antipyretic and antibacterial study of kabasura kudineer choornam

This study is designed to evaluate the anti-inflammaatory, antipyretic and antibacterial activity of aqueous extract of Kabasurakudineerchoornam (AEKKC). The phenol and flavonoid content were estimated by Folin-Ciocalteu and Aluminium chloride colorimetric method. The in vitro antioxidant potential was determined by DPPH and ABTS radical scavenging activity. The extract did not show any signs of toxicity upto 2000 mg/kg in rats. The anti-inflammatory activity of the extract was evaluated by carrageenan-induced paw edema and histamine induced paw edema. Oral administration of AEKKC at 200 and 400 mg/kg showeed significant reduction (P<0.05) in mean paw edema volume in both carrageenan and histamine induced inflammation. The anti-pyretic activity of the extract (200 and 400 mg/kg) was studied by brewer’s yeast induced pyrexia model in which paracetamol (150 mg/kg) was used as standard. The extract showed significant protection (P<0.05) by reducing yeast evoked elevated body temperature. AEKKC also exhibited antibacterial activity by showing zone of inhibition via disc diffusion method. The results of the study prove that AEKKC has significant anti-inflammatory, antipyretic and antimicrobial activity.