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The study was aimed to evaluate the anti-granuloma activity of the fresh leave sap of Mukia maderaspatna. Anti -granuloma this was evaluated using the subcutaneous cotton pellet implantation of cotton pellets-induced granuloma formation in rats. Diclofenac Sodium (25mg/kg) has been used as the drug of reference. The inhibition of granuloma-tissue formation by the fresh leave sap of Mukia maderaspatna was found to be statistically Significant (p