Ameliorative effect of psidium guajava leaves on ulcerative colitis

Inflammatory bowel disease (IBD) is a common chronic inflammatory disease of the gastrointestinal tract. There are two main subtypes of IBD; Crohn’s disease (CD) and ulcerative colitis (UC). The leaves of Psidium guajava, belonging to the family Myrtaceae were evaluated for its efficacy in ameliorating the acetic acid induced Ulcerative colitis. Male albino Wistar rats were randomly divided into five groups. Group 1 was given the vehicle tween 80, group II received 2 ml of 4% acetic acid solution on 8th day intrarectally, group III was given 2 ml of 4% acetic acid solution once intrarectally on 8th day and 2mg/kg of prednisolone orally for 3 days starting from the day of acetic acid treatment. Group IV and V received 7 days pretreatment with 250 mg/kg and 500 mg/kg of ethanolic leaf extract of Psidium guajava (PGEL) respectively and 2 ml of 4% acetic acid solution once intrarectally on 8th day. Drug treatment was continued till 10th day. The rats were sacrificed on 11th day and the haematological, macroscopical and biochemical parameters were assessed. Pre-treatment with the extract improved the haematological parameters, body weight and the stool consistency score as compared to positive control.