Alteration of antioxidant status and increased lipid-peroxidation levels in rheumatoid arthritis and osteoarthritis patients compared with normal individuals

Back Ground: Rheumatoid Arthritis is a chronic multisystem disease of unknown etiology. The characteristic feature of Rheumatoid arthritis is persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution. Osteoarthritis is one of the most prevalent and disabiling chronic diseases affecting elderly. The objective of this study to evaluate the non-enzymatic antioxidant and status of lipid-peroxidation status in patients suffering RA and OA compare with normal individuals. In this study lipid-peroxidation is a marker of oxidative stress measured by MDA.
Materials and Methods: in the present study we take total 300 patients in which 100 Rheumatoid arthritis patients (RA), 100 Osteoarthritis Patients (OA) and 100 control means these people have not any disease. In this study we evaluate serum lipid-peroxidation by Utleys methods and non enzymatic antioxidant (Vitamin E & Vitamin C) measured by Emer Engel and Carl A Burtis Method with the help of colourimeter.
Result: In this study we found increased lipid-peroxidation and decreased vitamin E and Vitamin C levels. These results are highly significant in both the group as compared to control.
Conclusion: In the present study altered non enzymatic antioxidant and increased MDA levels shows that generation of free radical is a causative factor of rheumatoid arthritis and osteoarthritis.