Aggressive central giant cell granuloma of mandible- A Case Report

Central giant cell granuloma (CGCG) is a benign intraosseous osteolytic tumor of the jaws with an unknown etiology. Clinically and radiologically, there are two variants, aggressive and non-aggressive. The lesion usually occurs in patients younger than 30 years. Histologically identical lesions occur in patients with known genetic lesions such as cherubism, Noonan syndrome, or neurofibromatosis type 1. Surgical curettage or in aggressive lesions, resection, is the most common therapy. Histologically this lesion consists of cellular fibrotic tissue with multinucleated giant cells, multiple foci of hemorrhage and trabeculea of woven bone.